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Notice Summary

Title:
UK-Southampton: 19/44 Nutrient Enriched Diet for Babies with a Brain Injury
Document Ref:
GB003ZM291343
Document Type:
Contract Notice - Other
Published By:
National Institute for Health Research
Date Published:
28 March 2019
Deadline Date:
04 December 2019
Document Source:
Framework/DPS:
No
Alert Profile:
Labels:

Notice Abstract

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic: 19/44 Nutrient enriched diet for babies with a brain injury Rationale: Perinatal brain injury, often as a result of either prematurity or oxygen deprivation (hypoxic ischaemic encephalopathy, HIE) around the time of birth, is associated with both short-term complications and increased risk of cognitive, motor and behavioural problems in the longer term, which can vary in severity depending on the location and extent of the damage inflicted. Brain injury during the perinatal period is particularly damaging, as this is a period of critical brain growth and development. However, this period also offers a ‘window of opportunity’ for intervention. Evolving understanding of the brain’s capacity for plasticity (its ability to be functionally altered) during early life means targeted interventions can be implemented to mitigate the damage. Improved early (in hospital) nutrition, to increase the supply of essential nutrients to the growing brain, is one such intervention that has demonstrated improved neurodevelopmental outcomes in preterm babies in the form of improved formula and breastmilk fortification. However, the critical period of brain plasticity continues throughout the first year of life so the question remains as to whether increased nutrients throughout this time could improve growth and neurodevelopmental outcomes, particularly among babies who have had a brain injury and are simultaneously at significantly increased risk of poor outcomes yet able to tolerate additional nutrient intakes. Recognising the inherent physiological and developmental differences between prematurity-related brain injury and term HIE-related brain injury, applicants should ensure sub-groups are adequately powered to answer the question. The role of breastfeeding should be addressed as should the potential for contamination between the arms of the trial.

Notice Details

CONTRACT NOTICE – NATIONAL

SERVICES

1 Authority Details

1.1

Authority Name and Address

National Institute for Health Research
N/A
Southampton UK
N/A N/A
N/A

1.2

Address from which documentation may be obtained

As in 1.1

1.3

Completed documents must be returned to:

As in 1.1

2 Contract Details

2.1

Title

19/44 Nutrient Enriched Diet for Babies with a Brain Injury

2.2

Description of the goods or services required

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic:

19/44 Nutrient enriched diet for babies with a brain injury

Rationale:

Perinatal brain injury, often as a result of either prematurity or oxygen deprivation (hypoxic ischaemic encephalopathy, HIE) around the time of birth, is associated with both short-term complications and increased risk of cognitive, motor and behavioural problems in the longer term, which can vary in severity depending on the location and extent of the damage inflicted.

Brain injury during the perinatal period is particularly damaging, as this is a period of critical brain growth and development. However, this period also offers a ‘window of opportunity’ for intervention. Evolving understanding of the brain’s capacity for plasticity (its ability to be functionally altered) during early life means targeted interventions can be implemented to mitigate the damage. Improved early (in hospital) nutrition, to increase the supply of essential nutrients to the growing brain, is one such intervention that has demonstrated improved neurodevelopmental outcomes in preterm babies in the form of improved formula and breastmilk fortification.

However, the critical period of brain plasticity continues throughout the first year of life so the question remains as to whether increased nutrients throughout this time could improve growth and neurodevelopmental outcomes, particularly among babies who have had a brain injury and are simultaneously at significantly increased risk of poor outcomes yet able to tolerate additional nutrient intakes. Recognising the inherent physiological and developmental differences between prematurity-related brain injury and term HIE-related brain injury, applicants should ensure sub-groups are adequately powered to answer the question. The role of breastfeeding should be addressed as should the potential for contamination between the arms of the trial.

2.3

Notice Coding and Classification

2.4

Total quantity or scope of tender

3 Conditions for Participation

3.1

Minimum standards and qualification required

4 Administrative Information

4.1

Type of Procedure

The procedure type is unknown.

4.2

Reference number attributed to the notice by the contracting authority

19/44

4.3

Time Limits

   04-12-2019  Time 13:00

4.5

Language or languages in which tenders or requests to participate can be drawn up

EN 

4.6

Tender Submission Postbox

5 Other Information

5.1

Additional Information

Please visit the following portal to view this notice:

https://www.nihr.ac.uk/funding-and-support/funding-opportunities/1944-nutrient-enriched-diet-for-babies-with-a-brain-injury/10572

The deadline for applications is 1pm, 4 December 2019.

(MT Ref:291343)

5.2

Additional Documentation

5.3

Publication date of this notice

 28-03-2019

Current Notes