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Notice Summary

Title:
UK-Southampton: 19/25 Anaesthesia for Arteriovenous Fistula Formation
Document Ref:
GB003ZM291152
Document Type:
Contract Notice - Other
Published By:
National Insttitute for Health Research
Date Published:
27 March 2019
Deadline Date:
18 September 2019
Document Source:
Framework/DPS:
No
Alert Profile:
Labels:

Notice Abstract

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic: 19/25 Anaesthesia for arteriovenous fistula formation Rationale: The number of patients reaching end stage renal failure and requiring renal replacement therapy continues to increase year on year with a lack of donor organs leaving many thousands of patients on long-term haemodialysis. Surgical creation of an arteriovenous fistula (AVF) is the preferred mechanism for renal dialysis vascular access. This surgical procedure joins an artery and a vein in the arm to produce a blood vessel larger and stronger than usual which, once established and fully healed, allows repeated needle puncture for the dialysis to proceed. The failure rate of AVFs is about 50% at one year, thus any change in practice which might improve AVF patency could make an important difference to patient outcomes and potentially subsequent resource use. A number of small single centre studies have shown that if regional anaesthesia is used rather than local anaesthesia for the AVF creation procedure, the failure rate is lower. Administration of regional anaesthesia takes longer than that for local and requires a skilled anaesthetist (not required for the local), and thus the up-front costs are higher. However, these could be offset if subsequent patient outcomes are improved and there is a reduced need for re-operation/intervention. A definitive, adequately powered, multi-centre randomised trial with associated cost-effectiveness analysis is therefore proposed to help inform clinical practice.

Notice Details

CONTRACT NOTICE – NATIONAL

SERVICES

1 Authority Details

1.1

Authority Name and Address

National Insttitute for Health Research
N/A
Southampton UK
N/A N/A
N/A

1.2

Address from which documentation may be obtained

As in 1.1

1.3

Completed documents must be returned to:

As in 1.1

2 Contract Details

2.1

Title

19/25 Anaesthesia for Arteriovenous Fistula Formation

2.2

Description of the goods or services required

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic:

19/25 Anaesthesia for arteriovenous fistula formation

Rationale:

The number of patients reaching end stage renal failure and requiring renal replacement therapy continues to increase year on year with a lack of donor organs leaving many thousands of patients on long-term haemodialysis.

Surgical creation of an arteriovenous fistula (AVF) is the preferred mechanism for renal dialysis vascular access. This surgical procedure joins an artery and a vein in the arm to produce a blood vessel larger and stronger than usual which, once established and fully healed, allows repeated needle puncture for the dialysis to proceed.

The failure rate of AVFs is about 50% at one year, thus any change in practice which might improve AVF patency could make an important difference to patient outcomes and potentially subsequent resource use.

A number of small single centre studies have shown that if regional anaesthesia is used rather than local anaesthesia for the AVF creation procedure, the failure rate is lower. Administration of regional anaesthesia takes longer than that for local and requires a skilled anaesthetist (not required for the local), and thus the up-front costs are higher. However, these could be offset if subsequent patient outcomes are improved and there is a reduced need for re-operation/intervention. A definitive, adequately powered, multi-centre randomised trial with associated cost-effectiveness analysis is therefore proposed to help inform clinical practice.

2.3

Notice Coding and Classification

2.4

Total quantity or scope of tender

3 Conditions for Participation

3.1

Minimum standards and qualification required

4 Administrative Information

4.1

Type of Procedure

The procedure type is unknown.

4.2

Reference number attributed to the notice by the contracting authority

19/25

4.3

Time Limits

   18-09-2019  Time 13:00

4.5

Language or languages in which tenders or requests to participate can be drawn up

EN 

4.6

Tender Submission Postbox

5 Other Information

5.1

Additional Information

Please visit the following portal to view this notice:

https://www.nihr.ac.uk/funding-and-support/funding-opportunities/1925-anaesthesia-for-arteriovenous-fistula-formation/10553

The deadline for applications is 1pm, 18 September 2019.

(MT Ref:291152)

5.2

Additional Documentation

5.3

Publication date of this notice

 27-03-2019

Current Notes