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Notice Summary

UK-Southampton: 19/37 Deep Infiltrating Endometriosis
GB003ZM291135
National Insttitute for Health Research
27 March 2019
31 July 2019
Contract Notice - Other
No

Notice Abstract

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic: 19/37 Deep infiltrating endometriosis Rationale: Endometriosis is a chronic condition which can have a significant impact on quality of life as well as fertility. The most aggressive form of the disease, deeply infiltrating endometriosis (DIE), involves, as the name suggests, endometriotic lesions invading other tissues and organs beside and near the uterus including, but not limited to the rectum and vagina. This can result in chronic pelvic pain, dysmenorrhoea, dyspareunia (difficult or painful sexual intercourse) and is linked to infertility. Various different pharmacological treatments might be used including pain killers (NSAIDs or even opioids) as well as a variety of different hormone replacement medications or contraceptives but the overall evidence of their effectiveness is equivocal. Surgery (conservative or complete resection of affected tissue) is an alternative treatment option with some advocating it should be offered as a primary treatment option. For some, surgery might be a last resort but for others this might be preferable to long term medical management. Although laparoscopic surgery has been shown to be relatively safe and effective for treatment of DIE and resolution of symptoms, there are no adequately powered trials to compare early surgery with optimal long term medical management. Only with such a trial, as proposed here, will clinicians have the necessary evidence on which to base their recommendations when having discussions with patients about the different treatment options available.

Notice Details

CONTRACT NOTICE – NATIONAL

SERVICES

1 Authority Details

1.1

Authority Name and Address


National Insttitute for Health Research

N/A

Southampton


UK

N/A

N/A


N/A

1.2

Address from which documentation may be obtained

As in 1.1

1.3

Completed documents must be returned to:

As in 1.1

2 Contract Details

2.1

Title

19/37 Deep Infiltrating Endometriosis

2.2

Description of the goods or services required

The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic:

19/37 Deep infiltrating endometriosis

Rationale:

Endometriosis is a chronic condition which can have a significant impact on quality of life as well

as fertility. The most aggressive form of the disease, deeply infiltrating endometriosis (DIE),

involves, as the name suggests, endometriotic lesions invading other tissues and organs beside

and near the uterus including, but not limited to the rectum and vagina. This can result in chronic

pelvic pain, dysmenorrhoea, dyspareunia (difficult or painful sexual intercourse) and is linked to

infertility.

Various different pharmacological treatments might be used including pain killers (NSAIDs or even

opioids) as well as a variety of different hormone replacement medications or contraceptives but

the overall evidence of their effectiveness is equivocal. Surgery (conservative or complete

resection of affected tissue) is an alternative treatment option with some advocating it should be

offered as a primary treatment option. For some, surgery might be a last resort but for others this

might be preferable to long term medical management.

Although laparoscopic surgery has been shown to be relatively safe and effective for treatment of

DIE and resolution of symptoms, there are no adequately powered trials to compare early surgery

with optimal long term medical management. Only with such a trial, as proposed here, will clinicians

have the necessary evidence on which to base their recommendations when having discussions

with patients about the different treatment options available.

2.3

Notice Coding and Classification

2.4

Total quantity or scope of tender

3 Conditions for Participation

3.1

Minimum standards and qualification required

4 Administrative Information

4.1

Type of Procedure

The procedure type is unknown.

4.2

Reference number attributed to the notice by the contracting authority

19/37

4.3

Time Limits

   31-07-2019  Time 13:00

4.5

Language or languages in which tenders or requests to participate can be drawn up

EN 

4.6

Tender Submission Postbox

5 Other Information

5.1

Additional Information

Please visit the following portal to view this notice:

https://www.nihr.ac.uk/funding-and-support/funding-opportunities/1937-deep-infiltrating-endometriosis/10565

The deadline for applications is 1pm, 31 July 2019.

(MT Ref:291135)

5.2

Additional Documentation

5.3

Publication date of this notice

 27-03-2019