Description of the goods or services required
The Health Technology Assessment Programme is accepting stage 1 applications to their commissioned workstream for this primary research topic:
19/39 Minimally invasive operative interventions for bladder outlet obstruction due to benign prostatic hyperplasia
Lower urinary tract symptoms due to benign prostatic hyperplasia are a problem for many men as they become older. Operative intervention is only offered when symptoms have not responded to conservative management and drug treatment.
Transurethral resection of the prostate has been the most common form of surgery, but in recent years a number of different modalities of treatment have been developed and are available in the NHS. Techniques include laser ablation, enucleation techniques including Holmium Laser Enucleation of the Prostate (HoLEP), prostatic artery embolisation, urethral lift, urethral stents and water jet and water vapour ablation.
NICE has released Interventional Procedures guidance on a number of these techniques and given recommendations about their use and the need for further research. Most of the new techniques tend to be less invasive than TURP, have fewer serious side effects and some may be carried out as day case procedures.
However research has not yet provided definitive evidence of comparative benefit or cost effectiveness, or whether their use subsequently leads to repeat or more invasive surgery.
The purpose of this call is to provide new data on a number of interventions that may be carried out as day case procedures, including transurethral water vapour ablation, and to use indirect comparisons or network meta-analysis to compare multiple interventions.
Applicants should be mindful of recent studies such as the GOLIATH study, UK-ROPE and, the HTA UNBLOCS trial and explain how their research would add significantly to knowledge in this field, rather than duplicate recent research.