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Notice Summary

Title:
UK-Newcastle: Supply and Delivery of a Nano-HPLC System for LC-MS
Document Ref:
GB003ZM311667
Document Type:
Contract Notice - Other
Published By:
Newcastle University
Date Published:
15 October 2019
Deadline Date:
05 November 2019
Document Source:
Framework/DPS:
No
Alert Profile:
Labels:

Notice Abstract

(NU/1534) The Supply and Delivery of a Nano-HPLC System for LC-MS Mass spectrometry-based proteomics has been extensively used in the field of cell biology and immunology, allowing the quantification of thousands of proteins as well as their modifications, localization, and dynamics for understanding cellular functions and processes on molecular level. Proteomics often provides a hypothesis-free and systems-wide characterisation of cellular or organellar proteomes. A standard proteomics workflow includes the following steps: extraction of proteins from cells or tissue, protein digestion by a protease into peptides, separation of peptides by liquid chromatography with online analysis of peptides by tandem mass spectrometry (LC-MS/MS), database-search for protein identification and software based quantification of the peptide ion intensities. We have in recent years successfully applied proteomics to a wide range of biological questions. We have analysed complex mammalian proteomes and subproteomes such as phosphoproteomes and ubiquitinomes. These subproteomes are often only available in very small sample amounts and thus we require high sensitivity for our proteomics analyses. Moreover, we are currently moving into clinical proteomics where we will analyse hundreds or even thousands of patient samples. We therefore require a robust LC-MS system that can perform many hundreds of analyses with minimal sample carryover and short inter-run overhead. Keywords Non EU Tender, LC-MS, Nano-HPLC System

Notice Details

CONTRACT NOTICE – NATIONAL

SUPPLIES

1 Authority Details

1.1

Authority Name and Address

Newcastle University
N/A
Newcastle UK
Emma Barksby N/A
emma.barksby@ncl.ac.uk N/A

1.2

Address from which documentation may be obtained

As in 1.1

1.3

Completed documents must be returned to:

As in 1.1

2 Contract Details

2.1

Title

Supply and Delivery of a Nano-HPLC System for LC-MS

2.2

Description of the goods or services required

(NU/1534) The Supply and Delivery of a Nano-HPLC System for LC-MS

Mass spectrometry-based proteomics has been extensively used in the field of cell biology and immunology, allowing the quantification of thousands of proteins as well as their modifications, localization, and dynamics for understanding cellular functions and processes on molecular level. Proteomics often provides a hypothesis-free and systems-wide characterisation of cellular or organellar proteomes. A standard proteomics workflow includes the following steps: extraction of proteins from cells or tissue, protein digestion by a protease into peptides, separation of peptides by liquid chromatography with online analysis of peptides by tandem mass spectrometry (LC-MS/MS), database-search for protein identification and software based quantification of the peptide ion intensities. We have in recent years successfully applied proteomics to a wide range of biological questions. We have analysed complex mammalian proteomes and subproteomes such as phosphoproteomes and ubiquitinomes. These subproteomes are often only available in very small sample amounts and thus we require high sensitivity for our proteomics analyses. Moreover, we are currently moving into clinical proteomics where we will analyse hundreds or even thousands of patient samples. We therefore require a robust LC-MS system that can perform many hundreds of analyses with minimal sample carryover and short inter-run overhead.

Keywords

Non EU Tender, LC-MS, Nano-HPLC System

2.3

Notice Coding and Classification

2.4

Total quantity or scope of tender

Estimated contract dates

Start date 23/11/2019

End date 28/11/2019

Region(s) of supply

UNITED KINGDOM

3 Conditions for Participation

3.1

Minimum standards and qualification required

4 Administrative Information

4.1

Type of Procedure

The procedure type is unknown.

4.2

Reference number attributed to the notice by the contracting authority

DN441728

4.3

Time Limits

   05-11-2019  Time 12:00

4.5

Language or languages in which tenders or requests to participate can be drawn up

EN 

4.6

Tender Submission Postbox

5 Other Information

5.1

Additional Information

Please visit the following portal to view this notice:

https://procontract.due-north.com/Advert?advertId=4ac50b62-8aee-e911-80fa-005056b64545

Expression of interest deadline : 05/11/2019 at 12:00 hrs

(MT Ref:311667)

5.2

Additional Documentation

5.3

Publication date of this notice

 15-10-2019

Current Notes